SYNTHESIS OF AMINO DERIVATIVES OF MONOTHIO- AND DITHIO- ANALOGUES OF CYCLOHEXANESPIRO-5-HYDANTOIN

Authors

  • Marin Marinov

DOI:

https://doi.org/10.46687/jsar.v2i1.45

Keywords:

cyclohexanespiro-5-hydantoin, amino derivatives, thio-analogues, thionation

Abstract

This article presents methods for synthesis of 3-amino derivatives of cyclohexanespiro-5-(2-thiohydantoin) and cyclohexanespiro-5-(2,4-dithiohydantoin). It was found out that the treatment of cyclohexanespiro-5-(2-thiohydantoin) with hydrazine hydrate under different reaction conditions led to obtaining of 3-amino derivative and 2-hydrazone of the initial compound. As a result of thionation of 3-aminocyclohexanespiro-5-hydantoin with P4S10 or Lawesson’s reagent, the corresponding dithio-analogue was synthesized. The structures of the products obtained were verified by IR, 1H NMR, 13C NMR and mass spectral data.

Author Biography

Marin Marinov

FACULTY OF PLANT PROTECTION AND AGROECOLOGY, AGRICULTURAL UNIVERSITY – PLOVDIV

References

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Published

04.03.2023

How to Cite

Marinov, M. (2023). SYNTHESIS OF AMINO DERIVATIVES OF MONOTHIO- AND DITHIO- ANALOGUES OF CYCLOHEXANESPIRO-5-HYDANTOIN. JOURNAL SCIENTIFIC AND APPLIED RESEARCH, 2(1), 66–73. https://doi.org/10.46687/jsar.v2i1.45