SYNTHESIS OF AMINO DERIVATIVES OF MONOTHIO- AND DITHIO- ANALOGUES OF CYCLOHEXANESPIRO-5-HYDANTOIN
DOI:
https://doi.org/10.46687/jsar.v2i1.45Keywords:
cyclohexanespiro-5-hydantoin, amino derivatives, thio-analogues, thionationAbstract
This article presents methods for synthesis of 3-amino derivatives of cyclohexanespiro-5-(2-thiohydantoin) and cyclohexanespiro-5-(2,4-dithiohydantoin). It was found out that the treatment of cyclohexanespiro-5-(2-thiohydantoin) with hydrazine hydrate under different reaction conditions led to obtaining of 3-amino derivative and 2-hydrazone of the initial compound. As a result of thionation of 3-aminocyclohexanespiro-5-hydantoin with P4S10 or Lawesson’s reagent, the corresponding dithio-analogue was synthesized. The structures of the products obtained were verified by IR, 1H NMR, 13C NMR and mass spectral data.
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